小儿高级别胶质瘤同步放化疗：一项I期研究

Simultaneous radiochemotherapy in pediatric patients with high-grade glioma: a phase I study.

作者信息

Wolff Johannes E A, Wagner Sabine, Sindichakis Marina, Pietsch Thorsten, Gnekow Astrid, Kortmann Rolf-Dieter, Sträter Ronald, Kuehl Joachim

机构信息

Klinik St. Hedwig, Steinmetzstr. 1-3, 93049 Regensburg, Germany.

出版信息

Anticancer Res. 2002 Nov-Dec;22(6B):3569-72.

PMID:12552957

Abstract

BACKGROUND

Sandwich chemotherapy as first postoperative treatment might cause resistance to ensuing irradiation. Simultaneous radiochemotherapy might prevent this.

PATIENTS AND METHODS

Twenty-nine children with high-grade glioma were treated from 1997-1999. The median age was 11.1 years. Tumor locations included: cerebral cortex 12, deep cerebral locations 11, cerebellum 3, spinal cord 3. Pons was excluded. Total (n = 9), subtotal (n = 3) and partial (n = 9) tumor resection or biopsy (n = 7) were followed by radiochemotherapy: fractionated radiation (1.8 Gyld up to 59.4 Gy) was given simultaneously with two cycles of chemotherapy (cisplatin 20 mg/m2/d x 5d, etoposide 100 mg/m2/d x 3d, and cisplatin, etoposide, ifosfamide: 1.5 g/m2/d). The data of a previous protocol (Cancer 89: 2131-7, 2000) in the same population were used as controls.

RESULTS

Early progressive disease (PD 2 out of 25 patients) was significantly less frequent as compared to the control group (p = 0.031). The toxicity appeared tolerable.

摘要

背景

三明治化疗作为术后首次治疗可能会导致对后续放疗产生耐药性。同步放化疗可能会预防这种情况。

患者与方法

1997年至1999年对29例高级别胶质瘤患儿进行了治疗。中位年龄为11.1岁。肿瘤位置包括：大脑皮质12例，脑深部位置11例，小脑3例，脊髓3例。脑桥被排除在外。在全切除（n = 9）、次全切除（n = 3）、部分切除（n = 9）或活检（n = 7）后进行同步放化疗：分割放疗（1.8 Gy/天，总量达59.4 Gy）与两个周期的化疗（顺铂20 mg/m²/天×5天，依托泊苷100 mg/m²/天×3天，以及顺铂、依托泊苷、异环磷酰胺：1.5 g/m²/天）同时进行。同一人群中先前方案（《癌症》89: 2131 - 2137, 2000）的数据用作对照。