丹曲林的代谢产物5-羟基-1-((5-(对硝基苯基)糠叉基)-氨基)乙内酰脲的合成
Synthesis of 5-hydroxy-1-((5-(p-nitrophenyl)furfurylidene)-amino) hydantoin, a metabolite of dantrolene.
作者信息
White R L, Schwan T J
出版信息
J Pharm Sci. 1976 Jan;65(1).
PMID:1255409
Abstract
The synthesis and structural elucidation of 5-hydroxyl-1-[[5-(p-nitrophenyl)furfurylidene]amino]hydantoin, a compound proposed as a metabolite of dantrolene sodium, are reported. In addition, a chromatographic comparison of the biological and synthesized materials is made.
摘要
据报道，丹曲林钠的一种推测代谢产物5-羟基-1-[[5-(对硝基苯基)糠叉基]氨基]乙内酰脲的合成及结构解析已完成。此外，还对生物来源和合成来源的该物质进行了色谱比较。
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