Lovering E G, Mainville C A, Rowe M L
J Pharm Sci. 1976 Feb;65(2):207-10. doi: 10.1002/jps.2600650209.
The effects of common tablet excipients on the permeation of diazepam through polydimethylsiloxane membranes and on the turnover time of goldfish were studied. The permeability coefficient decreased and the turnover time increased in the presence of talc, polysorbate 80, and, possibly, fumed silicon dioxide, but these parameters were unaffected by lactose, microcrystalline cellulose, and starch.
研究了常见片剂辅料对安定透过聚二甲基硅氧烷膜的渗透作用以及对金鱼周转时间的影响。在滑石粉、聚山梨酯80以及可能的气相二氧化硅存在的情况下，渗透系数降低，周转时间增加，但这些参数不受乳糖、微晶纤维素和淀粉的影响。
