Bakken K, Landheim A S, Vaglum P
Centre for Addiction Issues, Department for Substance Abuse, Sanderud, Ottestad, Norway.
Alcohol Alcohol. 2003 Jan-Feb;38(1):54-9. doi: 10.1093/alcalc/agg012.
This study evaluated the primary/secondary distinction among substance misusers according to comorbid mental disorders.
A consecutive sample (n = 287) of DSM-IV substance dependents from public treatment facilities in two counties in Norway were assessed by the Composite International Diagnostic Interview. According to the debut of the first independent mental disorder, patients were divided into primary substance use disorder (SUD) (17%), secondary SUD (76%) and SUD in the same year as the first mental disorder (7%).
A lifetime substance-independent mental disorder was found in 90%. Forty-two per cent had a combination of substance-independent and substance-induced mental disorders. Five per cent had substance-induced mental disorders only. Primary SUD patients comprised less women, and a lower number of substance-independent mental disorders. Secondary SUD patients had more major depression, phobic disorders and obsessive-compulsive disorder. There were no differences between primary SUD and secondary SUD regarding the number of substance-induced disorders or the pattern of substance misuse.
Clinical differences between primary and secondary SUD were small and do not support the distinction.
本研究根据共病精神障碍评估物质滥用者的原发性/继发性差异。
采用复合国际诊断访谈对挪威两个县公共治疗机构中连续抽取的287名DSM-IV物质依赖者样本进行评估。根据首次独立精神障碍的首次发病情况,将患者分为原发性物质使用障碍(SUD)(17%)、继发性SUD(76%)以及与首次精神障碍同年发生的SUD(7%)。
90%的患者存在终身性物质非依赖性精神障碍。42%的患者同时患有物质非依赖性和物质所致精神障碍。5%的患者仅患有物质所致精神障碍。原发性SUD患者中女性较少,物质非依赖性精神障碍的数量也较少。继发性SUD患者患有更多的重度抑郁症、恐惧症和强迫症。原发性SUD和继发性SUD在物质所致障碍的数量或物质滥用模式方面没有差异。
原发性和继发性SUD之间的临床差异较小,不支持这种区分。