Grady R W, Graziano J H, Akers H A, Cerami A
J Pharmacol Exp Ther. 1976 Feb;196(2):478-85.
2,3-Dihydroxybenzoic acid has been identified as a potentially useful iron-chelating drug. Accordingly, we have evaluated a series of derivatives of hydroxylated benzoic acids for their ability to induce iron excretion in the iron-overloaded rat. In addition, we have examined a number of hydroxamic acids and some other naturally occurring iron-chelating agents. Of the 26 benzoic acid derivatives studied, none appeared to be more effective than 2,3-dihydroxybenzoic acid, for reasons which are discussed. Rhodotorulic acid, a hydroxamic acid produced by and isolated from cultures of Rhodotorula pilimanae, was the most effective of all the compounds studied in inducing iron excretion. When administered parenterally, rholotorulic acid induced iron excretion via both the urinary and the fecal routes and was more than twice as potent (on a weight basis) as desferrioxamine. Two ferrous chelators, alpha, alpha-dipyridyl ad 1,10-phenanthroline, induced a moderate amount of iron excretion, suggesting that a pool of ferrous iron may be available for chelation.
2,3 - 二羟基苯甲酸已被确认为一种潜在有用的铁螯合剂。因此，我们评估了一系列羟基苯甲酸衍生物在铁过载大鼠中诱导铁排泄的能力。此外，我们还研究了一些异羟肟酸和其他一些天然存在的铁螯合剂。在所研究的26种苯甲酸衍生物中，由于文中讨论的原因，似乎没有一种比2,3 - 二羟基苯甲酸更有效。红酵母酸是由皮膜红酵母培养物产生并分离得到的一种异羟肟酸，是所有研究化合物中诱导铁排泄最有效的。经肠胃外给药时，红酵母酸通过尿液和粪便途径诱导铁排泄，并且（以重量计）效力是去铁胺的两倍多。两种亚铁螯合剂，α,α - 联吡啶和1,10 - 菲咯啉，诱导了适量的铁排泄，这表明可能存在可用于螯合的亚铁池。
