乙酰唑胺对离子跨孤立绵羊瘤胃上皮转运的影响。
The effect of acetzolamide on Ion transport across isolated sheep rumen epithelium.
作者信息
Emanović D, Harrison F A, Keynes R D, Rankin J C
出版信息
J Physiol. 1976 Jan;254(3):803-12. doi: 10.1113/jphysiol.1976.sp011260.
Abstract
- The net fluxes of sodium and chloride from the lumen to the blood side of isolated sheep rumen epithelium were reduced by treatment of both sides of the epithelium with acetazolamide. 2. The changes in the net fluxes of sodium and chloride were significantly correlated and showed recovery after removal of acetazolamide. 3. The net flux of potassium from blood to lumen side of the epithelim was not affected by treatment with acetazolamide. 4. It is suggested that acetazolamide blocks coupled sodium and chloride transport which may be mediated through 'low-activity' carbonic anhydrase enzymes.
摘要
- 用乙酰唑胺处理离体绵羊瘤胃上皮的两侧，可使钠和氯从管腔向血液侧的净通量降低。2. 钠和氯净通量的变化显著相关，且在去除乙酰唑胺后显示出恢复。3. 上皮从血液到管腔侧的钾净通量不受乙酰唑胺处理的影响。4. 提示乙酰唑胺阻断了可能由“低活性”碳酸酐酶介导的钠和氯的偶联转运。
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