Kale O O
Am J Trop Med Hyg. 1975 Jul;24(4):600-5. doi: 10.4269/ajtmh.1975.24.600.
In a controlled field trial of treatment for dracontiasis, mebendazole (Vermox) was found to be effective in eliminating the adult worm and preventing clinical relapses, but it did not achieve significant amelioration of symptoms, subsidence of inflammation, or healing of ulcers. The failure is attributed to poor absorption and lack of anti-inflammatory action of the drug. Mebendazole was well tolerated and although two patients reported mild gastrointestinal disturbances, which may be attributed to the drug, the study confirms that mebendazole is one of the safest anthelmintics in current use and is in that respect ideal for mass therapy.
在一项麦地那龙线虫病治疗的对照现场试验中，发现甲苯达唑（肠虫清）在消除成虫和预防临床复发方面有效，但在缓解症状、减轻炎症或溃疡愈合方面未取得显著改善。治疗失败归因于药物吸收不良和缺乏抗炎作用。甲苯达唑耐受性良好，尽管有两名患者报告了轻度胃肠道不适（可能归因于该药物），但该研究证实甲苯达唑是目前使用的最安全的驱虫药之一，在这方面非常适合大规模治疗。
