Girerd X, Hanon O
Service de Médecine Interne, Hôpital Broussais, 96, rue Didot, 75014 Paris.
Ann Cardiol Angeiol (Paris). 1999 Sep;48(7):518-22.
The benefits of treatment of hypertension in the elderly have been demonstrated by the results of therapeutic trials conducted in subjects over the age of 60. In 1985, the EWPHE trial, which demonstrated that thiazide diuretics decreased the main cardiovascular complications observed in elderly hypertensives, opened the way to the demonstration of the preventive efficacy of other classes of antihypertensives. The high level of cardiovascular risk observed in the elderly explains why prescription of antihypertensives provides a greater benefit in elderly hypertensives than in younger hypertensives. In hypertensive patients over the age of 80, the benefits of drug-induced blood pressure reduction have been demonstrated in terms of prevention of nonfatal complications.
针对60岁以上人群开展的治疗试验结果已证实了老年高血压治疗的益处。1985年,EWPHE试验表明噻嗪类利尿剂可降低老年高血压患者中观察到的主要心血管并发症,为证明其他类别的抗高血压药物的预防效果开辟了道路。老年人中观察到的高心血管风险解释了为什么抗高血压药物的处方在老年高血压患者中比在年轻高血压患者中带来更大的益处。在80岁以上的高血压患者中,药物引起的血压降低在预防非致命并发症方面的益处已得到证实。