Gueyffier F
Service de cardiologie, Hôpital Louis-Pradel, Lyon.
Rev Prat. 1999 Mar 1;49(5):512-8.
Therapeutic trials in hypertension taught us that a strategy based on a thiazide diuretic, or a beta-blocker as first-line drug, has reduced significantly the incidence of stroke (relative risk reduction: -35%), major coronary events (-14%), cardiovascular death (-18%) and heart failure (-42%). The level of cardiovascular risk, taking into account classical risk factors, multiplied by relative risk, offers the best estimate of therapeutic absolute benefit. In terms of prevention, being treated seems to be more important than the level of blood pressure that has been reached.
高血压治疗试验告诉我们，以噻嗪类利尿剂或β受体阻滞剂作为一线药物的治疗策略，已显著降低了中风的发生率（相对风险降低：-35%）、主要冠状动脉事件（-14%）、心血管死亡（-18%）和心力衰竭（-42%）。考虑到经典风险因素，心血管风险水平乘以相对风险，可提供治疗绝对获益的最佳估计。在预防方面，接受治疗似乎比所达到的血压水平更为重要。
