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眼眶粒细胞肉瘤:急性髓细胞白血病的一种不寻常表现。

Orbital granulocytic sarcoma: an unusual presentation of acute myelocytic leukemia.

作者信息

Stein-Wexler Rebecca, Wootton-Gorges Sandra L, West Daniel C

机构信息

Department of Radiology, University of California, Davis Medical Center and U.C. Davis Children's Hospital, 4860 Y St. Suite 3100, Sacramento, CA 95817, USA.

出版信息

Pediatr Radiol. 2003 Feb;33(2):136-9. doi: 10.1007/s00247-002-0834-0. Epub 2002 Nov 12.

Abstract

Granulocytic sarcoma is an unusual manifestation of acute myelogenous leukemia in children and presents a diagnostic dilemma when it precedes the development of systemic disease. We present CT and MRI findings of an extraconal mass proven to be granulocytic sarcoma in a 6-year-old otherwise healthy boy with several months' history of worsening unilateral proptosis. This case is unique in providing exquisite CT and MRI correlation and in demonstrating rapid response to therapy. Further, as cytogenetics were positive for the t(8,21) translocation, this case provides opportunity for discussion of the associated incidence of this translocation and concomitant better prognosis.

摘要

粒细胞肉瘤是儿童急性髓系白血病的一种罕见表现,当它先于全身疾病出现时会带来诊断难题。我们报告了一名6岁健康男孩的CT和MRI检查结果,该男孩有几个月单侧眼球突出加重的病史,其眶锥外肿块经证实为粒细胞肉瘤。该病例的独特之处在于提供了精确的CT与MRI相关性,并显示出对治疗的快速反应。此外,由于细胞遗传学检测显示t(8,21)易位呈阳性,该病例为讨论这种易位的相关发生率及随之而来的较好预后提供了机会。

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