[粒细胞肉瘤，一项诊断挑战：3例儿科病例]

[Granulocytic sarcoma, a diagnostic challenge: 3 pediatric cases].

作者信息

Rénard C, Girard S, Pracros J P, Dijoud F, André J-M, Mialou V, Bertrand Y

机构信息

Institut d'hématologie et d'oncologie pédiatrique, 1, place Joseph-Renaut, 69008 Lyon, France.

出版信息

Arch Pediatr. 2010 Feb;17(2):149-53. doi: 10.1016/j.arcped.2009.10.018. Epub 2009 Nov 27.

DOI:10.1016/j.arcped.2009.10.018

PMID:19945260

Abstract

Granulocytic sarcoma (GS) is a rare extramedullary tumor frequently associated with acute myeloblastic leukemia (AML). We report 3 cases of pediatric granulocytic sarcomas with various locations: skin, orbit, and bowel. Cases 1 and 2 were associated with AML; case 3 was isolated. In all 3 cases, the diagnosis was delayed or initially missed. Pathology and immunohistochemistry data identified the disease. GS is treated with chemotherapy, like AML. The prognosis of GS seems better than that of isolated AML.

摘要

粒细胞肉瘤（GS）是一种罕见的髓外肿瘤，常与急性髓细胞白血病（AML）相关。我们报告3例儿童粒细胞肉瘤，其发病部位各异：皮肤、眼眶和肠道。病例1和病例2与AML相关；病例3为孤立性。在所有3例病例中，诊断均被延迟或最初被漏诊。病理和免疫组化数据确诊了该疾病。GS的治疗方法与AML一样，采用化疗。GS的预后似乎优于孤立性AML。