Massinger C, Keilmann A
Klinik für Kommunikationsstörungen, Klinikum der Johannes-Gutenberg-Universität Mainz.
HNO. 2003 Jan;51(1):66-70. doi: 10.1007/s00106-002-0707-8.
We report on two patients affected by Cogan's syndrome since infancy.Cogan's syndrome is described as the association of abrupt or intermittent worsening of vestibulo-auditory function and non-syphilic interstitial keratitis or, in patients with "atypical" Cogan's syndrome, various severe, inflammatory eye diseases. The first patient was affected with different inflammatory eye diseases from her fifth year and became blind in one eye when she was 7 years old. At that time, a deterioration of her hearing ability was also diagnosed. The hearing loss progressed to a severe hearing disorder. The second patient suffered from different inflammatory eye diseases from his second year. When he was 3 years old,he was diagnosed with a severe hearing disorder that progressed.Cogan's syndrome was diagnosed when he was 13 years old. The recognition of Cogan's syndrome is particularly complex in young patients. The difficulty of the diagnosis requires a search for ophthalmic diseases in young children with acute and progressive vestibulo-auditory symptoms.
我们报告了两名自婴儿期起就患有科根综合征的患者。科根综合征被描述为前庭听觉功能突然或间歇性恶化与非梅毒性间质性角膜炎相关联，或者在“非典型”科根综合征患者中，与各种严重的炎症性眼病相关联。第一名患者从5岁起就患有不同的炎症性眼病，7岁时一只眼睛失明。当时，她的听力也被诊断出恶化。听力损失发展为严重的听力障碍。第二名患者从2岁起就患有不同的炎症性眼病。3岁时，他被诊断出患有严重的听力障碍且病情不断发展。他13岁时被诊断出患有科根综合征。在年轻患者中，科根综合征的识别尤为复杂。诊断的困难在于需要对有急性和进行性前庭听觉症状的幼儿进行眼科疾病排查。
