Mantel N, Blot W J
J Natl Cancer Inst. 1976 Feb;56(2):413-4. doi: 10.1093/jnci/56.2.413.
A method proposed by MacMahon for the differentiation between familial and environmental causes for disease has recently been applied to demonstrate an environmental etiology for Hodgkin's disease. It is shown that the method, which depends on the comparison of time-of-onset differences with age-at-onset differences for familial pairs with disease, is biased toward results suggestive of an environmental etiology when applied to data of the kind typically analyzed--data restricted to instances in which both members of a familial pair develop disease in a specified, limited time interval. Other features of such data are discussed.
麦克马洪提出的一种区分疾病家族性病因和环境性病因的方法，最近已被用于证明霍奇金病的环境病因。结果表明，该方法依赖于对患病家族配对的发病时间差异与发病年龄差异进行比较，当应用于典型分析的数据类型时，即仅限于家族配对的双方在特定有限时间间隔内都患病的情况时，该方法偏向于得出提示环境病因的结果。文中还讨论了此类数据的其他特征。
