[生物人工胰腺治疗糖尿病的研究]

[An investigation of bioartificial pancreas for treatment of diabetes mellitus].

作者信息

Yang H, Zhang P, Zhang C

机构信息

Department of Endocrinology, First University Hospital, West China University of Medical Sciences, Chengdu 610041.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2000 Jun;17(2):151-4.

PMID:12557768

Abstract

Bioartificial pancreas(BAP) made up of rat islet, agarose and collagen was developed in this experiment to cure the diabetes mellitus and prevent immune rejection of the islet xenograft. The insulin secretion function, immunoprotection and effect of BAP on the treatment of diabetes mellitus in mice were investigated. The results showed that the BAP maintained the insulin secretion function of islet, decreased the immunogenicity of islet xenograft and normalized the metabolic disturbances of carbohydrate in diabetic mice. These indicate that the BAP composed of the islet, agarose and collagen is an alternate approach to therapy for diabetes mellitus and to remission of immune rejection of the islet xenograft.

摘要

本实验研制了由大鼠胰岛、琼脂糖和胶原蛋白组成的生物人工胰腺（BAP），用于治疗糖尿病并防止胰岛异种移植的免疫排斥反应。研究了BAP的胰岛素分泌功能、免疫保护作用及其对小鼠糖尿病治疗的效果。结果表明，BAP维持了胰岛的胰岛素分泌功能，降低了胰岛异种移植的免疫原性，并使糖尿病小鼠的碳水化合物代谢紊乱恢复正常。这些结果表明，由胰岛、琼脂糖和胶原蛋白组成的BAP是治疗糖尿病和缓解胰岛异种移植免疫排斥反应的一种替代方法。