血管加压素可增加山羊的产奶量和乳脂浓度。

Vasopressin increases milk flow and milk fat concentration in the goat.

作者信息

Olsson K, Malmgren C, Olsson K K, Hansson K, Häggström J

机构信息

Department of Animal Physiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.

出版信息

Acta Physiol Scand. 2003 Feb;177(2):177-84. doi: 10.1046/j.1365-201X.2003.01055.x.

DOI:10.1046/j.1365-201X.2003.01055.x

PMID:12558554

Abstract

AIM

The aim of this study was to investigate whether physiological doses of vasopressin affect milk flow and milk composition in goats.

METHODS

Six goats were given vasopressin intravenously at doses of 0.1 ng kg(-1) min(-1) (a low dose, VL), 0.3 ng kg(-1) min(-1) (a medium dose, VM) and 1.0 ng kg(-1) min(-1) (a high dose, VH), oxytocin at 10 ng kg(-1) min(-1) and 0.15 m NaCl during 90 min at random.

RESULTS

Milk flow increased from 1.3 +/- 0.2 to 3.5 +/- 1.0 g min(-1) (VL), from 1.8 +/- 0.4 to 4.3 +/- 0.6 g min(-1) (VM) and from 1.5 +/- 0.2 to 7.9 +/- 0.9 g min(-1) (VH) during the first 30-min infusions (all P < 0.001), respectively, and then declined. The response to oxytocin corresponded to that of VH. Milk fat concentration increased from 2.1 +/- 0.1 to 3.3 +/- 0.4% during VH and from 2.8 +/- 0.6 to 4.1 +/- 0.6% during oxytocin (both P < 0.001), and tended to increase during VM and VL. The mammary blood flow of four goats was studied with ultrasound during VH and oxytocin infusion. Milk flow increased from 1.8 +/- 0.4 to 4.7 +/- 1.0 g min(-1) during VH and from 1.9 +/- 0.3 to 12.4 +/- 2.4 g min(-1) during oxytocin (both P < 0.001). Mammary blood flow decreased from 262 +/- 37 to 53 +/- 7 mL min(-1) (P < 0.001) during VH, but did not change during oxytocin.

CONCLUSION

We conclude that vasopressin increases milk flow and milk fat concentration and suggest that vasopressin, like oxytocin, acts on the myoepithelial cells.

摘要

目的

本研究旨在调查生理剂量的血管加压素是否会影响山羊的乳汁分泌量和乳汁成分。

方法

六只山羊被随机给予静脉注射血管加压素，剂量分别为0.1 ng kg⁻¹ min⁻¹（低剂量，VL）、0.3 ng kg⁻¹ min⁻¹（中剂量，VM）和1.0 ng kg⁻¹ min⁻¹（高剂量，VH），催产素剂量为10 ng kg⁻¹ min⁻¹，以及0.15 m NaCl，持续90分钟。

结果

在最初30分钟的输注过程中，乳汁分泌量分别从1.3±0.2增加到3.5±1.0 g min⁻¹（VL）、从1.8±0.4增加到4.3±0.6 g min⁻¹（VM）以及从1.5±0.2增加到7.9±0.9 g min⁻¹（VH）（均P<0.001），随后下降。对催产素的反应与VH相似。在VH期间，乳脂肪浓度从2.1±0.1增加到3.3±0.4%，在催产素期间从2.8±0.6增加到4.1±0.6%（均P<0.001），在VM和VL期间也有增加趋势。在VH和催产素输注期间，用超声研究了四只山羊的乳腺血流量。在VH期间，乳汁分泌量从1.8±0.4增加到4.7±1.0 g min⁻¹，在催产素期间从1.9±0.3增加到12.4±2.4 g min⁻¹（均P<0.001）。在VH期间，乳腺血流量从262±37降至53±7 mL min⁻¹（P<0.001），但在催产素期间没有变化。