伴有中央颞区棘波的良性癫痫：棘波触发功能磁共振成像显示躯体感觉皮层活动。
Benign epilepsy with centro-temporal spikes: spike triggered fMRI shows somato-sensory cortex activity.
作者信息
Archer John S, Briellman Regula S, Abbott David F, Syngeniotis Ari, Wellard R Mark, Jackson Graeme D
机构信息
Brain Research Institute, Neurosciences Building, Austin and Repatriation Medical Centre, Banksia Street, Heidelberg West, 3081, Victoria Australia.
出版信息
Epilepsia. 2003 Feb;44(2):200-4. doi: 10.1046/j.1528-1157.2003.02502.x.
OBJECTIVE
We performed spike triggered functional MRI (fMRI) in a 12 year old girl with Benign Epilepsy with Centro-temporal Spikes (BECTS) and left-sided spikes. Our aim was to demonstrate the cerebral origin of her interictal spikes.
METHODS
EEG was recorded within the 3 Tesla MRI. Whole brain fMRI images were acquired, beginning 2-3 seconds after spikes. Baseline fMRI images were acquired when there were no spikes for 20 seconds. Image sets were compared with the Student's t-test.
RESULTS
Ten spike and 20 baseline brain volumes were analysed. Focal activiation was seen in the inferior left sensorimotor cortex near the face area. The anterior cingulate was more active during baseline than spikes.
CONCLUSIONS
Left sided epileptiform activity in this patient with BECTS is associated with fMRI activation in the left face region of the somatosensory cortex, which would be consistent with the facial sensorimotor involvement in BECT seizures. The presence of BOLD signal change in other regions raises the possibility that the scalp recorded field of this patient with BECTs may reflect electrical change in more than one brain region.
目的
我们对一名患有中央颞区棘波的儿童良性癫痫（BECTS）且左侧有棘波的12岁女孩进行了棘波触发功能磁共振成像（fMRI）检查。我们的目的是证明其发作间期棘波的脑起源。
方法
在3特斯拉磁共振成像仪内记录脑电图。在棘波出现后2 - 3秒开始采集全脑fMRI图像。在无棘波持续20秒时采集基线fMRI图像。图像集采用学生t检验进行比较。
结果
分析了10个棘波和20个基线脑容积。在左侧面部区域附近的左下感觉运动皮层可见局灶性激活。前扣带回在基线期比棘波期更活跃。
结论
该BECTS患者的左侧癫痫样活动与体感皮层左侧面部区域的fMRI激活相关，这与BECT发作时面部感觉运动受累情况一致。其他区域存在血氧水平依赖（BOLD）信号变化增加了这样一种可能性，即该BECTS患者头皮记录的电场可能反映了不止一个脑区的电变化。
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