Wahner-Roedler Dietlind L, Reynolds Carol, Morton Marilyn J
Breast Clinic, Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Breast J. 2003 Jan-Feb;9(1):49-52. doi: 10.1046/j.1524-4741.2003.09117.x.
We describe a 45-year-old woman who presented with a spontaneous unilateral nipple discharge. With a negative breast examination and screening tests (mammography and ultrasonography) she underwent mammary ductography, which revealed a small 3-4 mm intraluminal filling defect. A core biopsy showed high-grade ductal carcinoma in situ (DCIS). An attempted wide local excision was unsuccessful, and the patient underwent a mastectomy. Pathologic assessment revealed high-grade DCIS and multiple foci of invasive mucinous ductal adenocarcinoma. Rare tumor cells were identified in the subcapsular sinuses in both sentinel lymph nodes. We report this case to point out the importance of the diagnostic examination for patients with a pathologic nipple discharge and review current and possible future diagnostic management.
我们描述了一位45岁出现自发性单侧乳头溢液的女性。乳腺检查及筛查试验（乳房X线摄影和超声检查）结果均为阴性，她接受了乳腺导管造影，结果显示管腔内有一个3 - 4毫米的小充盈缺损。粗针活检显示为高级别导管原位癌（DCIS）。尝试进行的广泛局部切除未成功，该患者接受了乳房切除术。病理评估显示为高级别DCIS和多个浸润性黏液性导管腺癌灶。在两个前哨淋巴结的被膜下窦中均发现了罕见的肿瘤细胞。我们报告此病例以指出对病理性乳头溢液患者进行诊断检查的重要性，并回顾当前及未来可能的诊断管理方法。
