淀粉样纤维对糖胺聚糖生物合成的刺激作用。
Stimulation of glycosaminoglycan biosynthesis by amyloid fibrils.
作者信息
Palmoski M J, Brandt K D
出版信息
Biochem J. 1975 Apr;148(1):145-7. doi: 10.1042/bj1480145.
Abstract
Since amyloid-laden organs have an increased glycosaminoglycan content, the effect of amyloid fibrils on glycosaminoglycan metabolism by normal fibroblasts was examined. In comparison with controls, synthesis of glycosaminoglycans, primarily hyaluronic acid, was increased by an average of 48 and 93% respectively when 0.1 and 1.0 mg of amyloid fibrils/ml was added to the cultures.
摘要
由于富含淀粉样蛋白的器官中糖胺聚糖含量增加，因此研究了淀粉样原纤维对正常成纤维细胞糖胺聚糖代谢的影响。与对照组相比，当向培养物中分别添加0.1和1.0毫克/毫升的淀粉样原纤维时，糖胺聚糖（主要是透明质酸）的合成分别平均增加了48%和93%。
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