ETO（MTG8）基因家族。

The ETO (MTG8) gene family.

作者信息

Davis J Nathan, McGhee Laura, Meyers Shari

机构信息

Department of Biochemistry and Molecular Biology F7-26, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport 71130, USA.

出版信息

Gene. 2003 Jan 16;303:1-10. doi: 10.1016/s0378-1119(02)01172-1.

DOI:10.1016/s0378-1119(02)01172-1

PMID:12559562

Abstract

Cloning and characterization of the 8;21 chromosomal breakpoint identified AML1 on chromosome 21 and ETO (MTG8) on chromosome 8, and the resultant chimeric gene product, AML-1/ETO. The ETO gene family now includes three human members encoding proteins composed of four evolutionarily conserved domains termed nervy homology regions (NHR) 1-4. ETO associates with N-CoR/Sin3a/HDAC complexes in vivo and acts as a corepressor for the promyelocytic zinc finger protein. Moreover, ETO is nuclear matrix attached at sites coincident with histone deacetylase enzymes and mSin3a. These data suggest that ETO proteins function as transcriptional corepressors. This review focuses on the ETO gene family in terms of expression and function. Specifically, the role of ETO as a co-repressor will be detailed. Additionally, the impact of this recent discovery on treatment of t(8;21)-containing leukemia will be discussed.

摘要

8号和21号染色体断点的克隆与特征分析确定了21号染色体上的AML1基因和8号染色体上的ETO（MTG8）基因，以及由此产生的嵌合基因产物AML-1/ETO。ETO基因家族目前包括三个人类成员，它们编码的蛋白质由四个进化上保守的结构域组成，称为神经同源区域（NHR）1-4。ETO在体内与N-CoR/Sin3a/HDAC复合物结合，并作为早幼粒细胞锌指蛋白的共抑制因子发挥作用。此外，ETO附着于与组蛋白脱乙酰酶和mSin3a重合的核基质位点。这些数据表明ETO蛋白作为转录共抑制因子发挥作用。本综述重点关注ETO基因家族的表达和功能。具体而言，将详细阐述ETO作为共抑制因子的作用。此外，还将讨论这一最新发现对含t(8;21)白血病治疗的影响。