膜内裂解蛋白酶：蛋白质和生物活性肽的可控释放

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.

作者信息

Weihofen Andreas, Martoglio Bruno

机构信息

Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), ETH-Hoenggerberg, 8093 Zurich, Switzerland.

出版信息

Trends Cell Biol. 2003 Feb;13(2):71-8. doi: 10.1016/s0962-8924(02)00041-7.

DOI:10.1016/s0962-8924(02)00041-7

PMID:12559757

Abstract

This review summarizes recent findings and common principles for intramembrane-cleaving proteases that catalyse critical steps in cell regulation and signalling and which are involved in diseases such as Alzheimer's disease and hepatitis C virus infection.

摘要

本综述总结了膜内裂解蛋白酶的近期研究发现和通用原则，这些蛋白酶催化细胞调节和信号传导中的关键步骤，并与阿尔茨海默病和丙型肝炎病毒感染等疾病有关。