Philippe Geneviève, De Mol Patrick, Zèches-Hanrot Monique, Nuzillard Jean-Marc, Tits Monique-Hanrot, Angenot Luc, Frédérich Michel
University of Liège, Natural and Synthetic Drugs Research Center, Laboratoire de Pharmacognosie, Avenue de l'Hôpital 1, B36, B-4000 Liège, Belgium.
Phytochemistry. 2003 Feb;62(4):623-9. doi: 10.1016/s0031-9422(02)00612-x.
In the course of our search for new antiplasmodial alkaloids from Strychnos icaja, we have isolated five alkaloids: three monomers, protostrychnine and genostrychnine, previously described in Strychnos nux-vomica, pseudostrychnine, already found in the leaves of the plant, a new bisindolic alkaloid, named strychnogucine C, and the first naturally occurring trimeric indolomonoterpenic alkaloid: strychnohexamine. This latter trimeric alkaloid presented an antiplasmodial activity against the FCA Plasmodium falciparum line near 1 microM.
在我们从伊卡马钱木中寻找新型抗疟生物碱的过程中，我们分离出了五种生物碱：三种单体，即之前在马钱子中描述过的原番木鳖碱和异番木鳖碱、已在该植物叶片中发现的假番木鳖碱、一种新的双吲哚生物碱，命名为马钱古辛C，以及首个天然存在的三聚吲哚单萜生物碱：马钱己胺。后一种三聚生物碱对恶性疟原虫FCA株系呈现出接近1微摩尔的抗疟活性。
