Tønnesen H Hjorth
Institute of Pharmacy, University of Oslo, Norway.
Pharmazie. 2002 Dec;57(12):820-4.
The natural compound curcumin was incorporated into various micellar systems in order to improve the water solubility and the hydrolytic and photochemical stability. The presence of micellar structures resulted in an increase in water solubility at pH 5 by a factor of at least 10(5). The hydrolytic stability of curcumin under alkaline conditions was strongly improved by incorporation into micelles while the photodecomposition rate was increased compared to curcumin in hydrogen bonding organic solvents or aqueous solutions. The ability of curcumin to act as a photosensitizer was dependent on the type of micelles and pH of the medium.
天然化合物姜黄素被纳入各种胶束系统，以提高其水溶性以及水解稳定性和光化学稳定性。胶束结构的存在使姜黄素在pH 5时的水溶性增加了至少10⁵倍。将姜黄素纳入胶束中，可显著提高其在碱性条件下的水解稳定性，而与在氢键有机溶剂或水溶液中的姜黄素相比，其光分解速率有所增加。姜黄素作为光敏剂的能力取决于胶束的类型和介质的pH值。
