Amani Shahin, Bagheri Garmarudi Amir, Rahmani Niloofar, Khanmohammadi Mohammadreza
Department of Chemistry, Faculty of Science, Imam Khomeini International University Qazvin Iran.
RSC Adv. 2019 Oct 10;9(55):32348-32356. doi: 10.1039/c9ra04739e. eCollection 2019 Oct 7.
Herein, the nanosized ZSM-5 zeolite was synthesized based on a fractional factorial experimental design by a hydrothermal method to study the optimum conditions for the synthesis and formation of the ZSM-5 zeolite by employing different conditions. The samples were synthesized without any organic template, and different conditions, such as the molar composition of the synthesis gel and reaction time, were applied in a wide range. Then, the samples were analysed by X-ray diffraction to investigate the formation of the zeolite ZSM-5, and the results were compared to obtain the optimum conditions for its synthesis. The obtained samples were characterized by SEM, FTIR spectroscopy and TGA. Then, the functionalization of nano zeolite ZSM-5 crystals with β-cyclodextrin (β-CD) was investigated. The zeolite surface was first functionalized with amino groups using an amino alkoxysilane. Then, toluene diisocyanate was reacted with the amino-terminated ZSM-5 zeolite crystals and used for the incorporation of β-CD its remaining isocyanate groups. After this, a drug delivery system (DDS) was prepared based on the cyclodextrin-modified zeolite with the curcumin anticancer drug, and its formation was studied under experimental conditions. The results of studies show that this drug delivery system has better characteristics than free curcumin in terms of stability and anti-proliferative and anti-inflammatory effects.
在此，基于分数因子实验设计，采用水热法合成了纳米ZSM - 5沸石，以研究在不同条件下合成和形成ZSM - 5沸石的最佳条件。在不使用任何有机模板的情况下合成样品，并在很宽的范围内应用不同条件，如合成凝胶的摩尔组成和反应时间。然后，通过X射线衍射分析样品以研究ZSM - 5沸石的形成，并比较结果以获得其合成的最佳条件。对所得样品进行扫描电子显微镜（SEM）、傅里叶变换红外光谱（FTIR）和热重分析（TGA）表征。然后，研究了用β - 环糊精（β - CD）对纳米ZSM - 5晶体进行功能化。首先使用氨基烷氧基硅烷对沸石表面进行氨基功能化。然后，甲苯二异氰酸酯与氨基封端的ZSM - 5沸石晶体反应，并用于引入β - CD及其剩余的异氰酸酯基团。在此之后，基于环糊精修饰的沸石与姜黄素抗癌药物制备了药物递送系统（DDS），并在实验条件下研究了其形成。研究结果表明，该药物递送系统在稳定性、抗增殖和抗炎作用方面比游离姜黄素具有更好的特性。
