两种来自黄芩的黄酮及其与GABAA受体复合物苯二氮䓬位点的结合亲和力。
Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex.
作者信息
Wang Hongyan, Hui Kwok-Min, Xu Suixu, Chen Yingjie, Wong J Tze Fei, Xue Hong
机构信息
Department of Natural Product Chemistry, Shenyang Pharmaceutical University, China.
出版信息
Pharmazie. 2002 Dec;57(12):857-8.
PMID:12561253
Abstract
A new flavone 6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone (1) together with one known flavone 5,7,2'-trihydroxy-6,8-dimethoxyflavone (2) were isolated from the roots of Scutellaria baicalensis Georgi. Their structures were elucidated on the basis of spectral evidence and their affinities for the benzodiazepine (BDZ) site of the GABAA receptor complex were evaluated with a radioligand receptor binding assay.
摘要
从黄芩根中分离出一种新的黄酮6,2'-二羟基-5,7,8,6'-四甲氧基黄酮（1）和一种已知黄酮5,7,2'-三羟基-6,8-二甲氧基黄酮（2）。基于光谱证据阐明了它们的结构，并通过放射性配体受体结合试验评估了它们对GABAA受体复合物苯二氮䓬（BDZ）位点的亲和力。
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