来自黄芩根的苯二氮䓬结合位点相互作用黄酮类化合物。
Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root.
作者信息
Liao J F, Wang H H, Chen M C, Chen C C, Chen C F
机构信息
Department of Pharmacology, National Yang-Ming University, Taipei, Taiwan, Republic of China.
出版信息
Planta Med. 1998 Aug;64(6):571-2. doi: 10.1055/s-2006-957517.
PMID:9776664
Abstract
A benzodiazepine binding assay directed separation led to the identification of 3 flavones baicalein (1), oroxylin A (2), and skullcapflavone II (3) from the water extract of Scutellaria baicalensis root. Compounds 1, 2, and 3 interacted with the benzodiazepine binding site of GABAA receptors with a Ki value of 13.1, 14.6 and 0.36 micromol/L, respectively.
摘要
一项针对苯二氮䓬结合试验的分离方法，从黄芩根的水提取物中鉴定出3种黄酮类化合物，即黄芩素（1）、白杨素（2）和黄芩黄酮II（3）。化合物1、2和3与GABAA受体的苯二氮䓬结合位点相互作用，其Ki值分别为13.1、14.6和0.36微摩尔/升。
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