Dai Honglian, Yan Yuhua, Cao Xianying, Li Shipu, Jia Li, Dong Weili
Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan 430070.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2002 Dec;19(4):552-5, 558.
To evaluate the sealing potential of self-designed root canal filling material made of calcium phosphate cement (alpha-TCP/TTCP, CPC), the apices of root canals of six adult dogs were purposely perforated and enlarged up to the No 40 instrument. Then CPC was used to fill the root canal. Mean while either calcium hydroxide (Ca(OH)2) paste or hydroxyapatite (HA) paste was used as control. The animals were killed at 4, 12, 20 weeks postoperatively. The different materials about ways of apical closure, restoration periapocal tissues and adaptability to the dentinal surface were observed by histomorphology and scanning electron microscopic. This study revealed that CPC had excellent biocompatibility and adaptability to the dentinal wall. Its osteoconduction can promote the formation of calcific barriers and healing of periapical tissue. The apex can be closed completely. Compared with the control pastes it has advantages of ease of manipulation and better sealing capability. The results showed that CPC could be used as a root canal filling material for pupless teeth with open apex and destructive periapical tissue.
为评估自行设计的由磷酸钙水泥（α-磷酸三钙/四钙磷酸盐，CPC）制成的根管充填材料的封闭潜力，特意将6只成年犬的根管根尖穿孔并扩大至40号器械。然后用CPC充填根管。同时，分别用氢氧化钙（Ca(OH)₂）糊剂或羟基磷灰石（HA）糊剂作为对照。术后4周、12周、20周处死动物。通过组织形态学和扫描电子显微镜观察不同材料在根尖封闭方式、根尖周组织修复以及与牙本质表面适应性方面的情况。本研究表明，CPC具有优异的生物相容性和对牙本质壁的适应性。其骨传导性可促进钙化屏障的形成和根尖周组织的愈合。根尖可完全封闭。与对照糊剂相比，它具有操作简便和封闭能力更好的优点。结果表明，CPC可用作根尖开放和根尖周组织破坏的无髓牙的根管充填材料。
