Xiao Rui, Song Yaoming
Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu 610041.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2002 Dec;19(4):703-7.
Spine fusion stabilize adjacent vertebral segments by achieving bone union. The preferred method of spine fusion involves decortication of the host bed and transplantation of autologous bone graft from the iliac crest. Although autologous bone grafting is the gold standard, this procedure has significant complication. Gene therapy represents the new frontier of medical science that holds much promise for the improvement of spinal arthrodesis. Studies have shown the efficacy in using liposome-mediated and adenovirus-mediated gene transfer of bone morphogenetic protein (BMP) and related gene in animal models. Several studies in which gene transfer has been used specifically to enchance spine fusion in animal models are reviewed. Current main areas of research, including the elucidation of gene expression profiles during bone formation and the development of new gene transfer vehicles, promises the development of clinically applicable techniques in the near future.
脊柱融合术通过实现骨融合来稳定相邻的椎体节段。脊柱融合术的首选方法包括对宿主床进行去皮质处理以及从髂嵴移植自体骨移植。尽管自体骨移植是金标准，但该手术有显著的并发症。基因治疗代表了医学科学的新前沿，对改善脊柱融合术有很大的前景。研究表明在动物模型中使用脂质体介导和腺病毒介导的骨形态发生蛋白（BMP）及相关基因的基因转移具有疗效。本文综述了几项在动物模型中专门使用基因转移来增强脊柱融合的研究。当前主要的研究领域，包括阐明骨形成过程中的基因表达谱以及开发新的基因转移载体，有望在不久的将来开发出临床适用的技术。
