Rogers P David, Barker Katherine S, Herring Vanessa, Jacob Melissa
Departments of Clinical Pharmacy and Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 26 South Dunlap Street, Memphis, TN 38163, USA.
J Antimicrob Chemother. 2003 Feb;51(2):405-8. doi: 10.1093/jac/dkg070.
The cytokine and chemokine response elicited by heat-treated amphotericin B (HT-AmB) was compared with that of untreated amphotericin B (AmB-DOC) in the human monocyte cell line THP-1. AmB-DOC produced dose-dependent increases in interleukin (IL)-1beta, IL-1alpha, tumour necrosis factor-alpha, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta at 2 h. HT-AmB induced cytokine and chemokine production at a lower level than those observed with corresponding concentrations of AmB-DOC, while retaining antifungal activity. These results indicate that heat treatment of amphotericin B may prove to be a cost-effective approach to improving the therapeutic index of this antifungal agent.
在人单核细胞系THP-1中，比较了热处理两性霉素B（HT-AmB）和未处理两性霉素B（AmB-DOC）引发的细胞因子和趋化因子反应。在2小时时，AmB-DOC使白细胞介素（IL）-1β、IL-1α、肿瘤坏死因子-α、巨噬细胞炎性蛋白（MIP）-1α和MIP-1β呈剂量依赖性增加。HT-AmB诱导的细胞因子和趋化因子产生水平低于相应浓度的AmB-DOC，同时保留抗真菌活性。这些结果表明，两性霉素B的热处理可能是提高这种抗真菌药物治疗指数的一种经济有效的方法。
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