志贺氏菌分离株对抗菌药物的耐药性不断增强。
Growing antimicrobial resistance of Shigella isolates.
作者信息
Ashkenazi Shai, Levy Itzhak, Kazaronovski Vered, Samra Zmira
机构信息
Department of Paediatrics A, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petah Tiqva 49202, Israel.
出版信息
J Antimicrob Chemother. 2003 Feb;51(2):427-9. doi: 10.1093/jac/dkg080.
Appropriate antibiotic treatment of shigellosis depends on identifying resistance patterns. By studying Shigella isolates in central Israel from 1998 to 2000, and comparing with the period 1991-1992, we identified a significantly increased resistance to tetracycline (from 23% to 87%, P < 0.00001), high resistance to trimethoprim-sulfamethoxazole (94%) and ampicillin (85%) and emerging resistance to quinolones (0.5-2%). These data mandate local monitoring of resistance and its consideration in empirical therapy.
志贺氏菌病的适当抗生素治疗取决于确定耐药模式。通过研究1998年至2000年以色列中部的志贺氏菌分离株，并与1991年至1992年期间进行比较，我们发现对四环素的耐药性显著增加（从23%增至87%，P<0.00001），对甲氧苄啶-磺胺甲恶唑（94%）和氨苄青霉素（85%）的耐药性较高，对喹诺酮类药物的耐药性正在出现（0.5%-2%）。这些数据要求对耐药性进行本地监测，并在经验性治疗中予以考虑。
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