Ashkenazi Shai, Levy Itzhak, Kazaronovski Vered, Samra Zmira
Department of Paediatrics A, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petah Tiqva 49202, Israel.
J Antimicrob Chemother. 2003 Feb;51(2):427-9. doi: 10.1093/jac/dkg080.
Appropriate antibiotic treatment of shigellosis depends on identifying resistance patterns. By studying Shigella isolates in central Israel from 1998 to 2000, and comparing with the period 1991-1992, we identified a significantly increased resistance to tetracycline (from 23% to 87%, P < 0.00001), high resistance to trimethoprim-sulfamethoxazole (94%) and ampicillin (85%) and emerging resistance to quinolones (0.5-2%). These data mandate local monitoring of resistance and its consideration in empirical therapy.
志贺氏菌病的适当抗生素治疗取决于确定耐药模式。通过研究1998年至2000年以色列中部的志贺氏菌分离株，并与1991年至1992年期间进行比较，我们发现对四环素的耐药性显著增加（从23%增至87%，P<0.00001），对甲氧苄啶-磺胺甲恶唑（94%）和氨苄青霉素（85%）的耐药性较高，对喹诺酮类药物的耐药性正在出现（0.5%-2%）。这些数据要求对耐药性进行本地监测，并在经验性治疗中予以考虑。
