在以色列南部两个不同人群的粪便培养物中分离出的志贺氏菌属对抗菌药物的耐药性的流行病学趋势和模式。
Epidemiological trends and patterns of antimicrobial resistance of Shigella spp. isolated from stool cultures in two different populations in Southern Israel.
机构信息
Pediatric Emergency Medicine Department, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Pediatric Infectious Disease Unit, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
Diagn Microbiol Infect Dis. 2014 Mar;78(3):287-91. doi: 10.1016/j.diagmicrobio.2013.12.005. Epub 2013 Dec 14.
Southern Israel is inhabited by Bedouins, living in conditions similar to developing countries and Jews, living in conditions similar to developed countries. We determined the epidemiology of Shigella spp. in these populations. We retrospectively reviewed Shigella spp. stool isolations between 2005-2009. Overall, 3295 isolates were analyzed. S. sonnei was isolated in 2057/3295 (62.4%) and S. flexneri in 1058 (32.1%). S. sonnei was isolated in 1567/1707 (91.8%) from Jewish patients and S. flexneri in 931/1542 (60.4%) from Bedouin patients. Ampicillin resistance increased linearly from 217/373 (58.2%) in 2005 to 186/256 (72.7%) in 2009, (P < 0.001). Trimethoprim-sulfamethoxazole resistance decreased linearly from 328/373 (87.9%) in 2005 to 133/256 (51.9%) in 2009 (P < 0.001). Higher resistance of Shigella spp. to ampicilin and trimethoprim-sulfamethoxazole were found in Jewish patients: 1527/1706 (89.5%) versus 977/1542 (63.4%) (P < 0.0001), 1635/1706 (95.8%) versus 1026/1542 (66.5%) (P < 0.0001). The epidemiology of Shigella spp. infections can differ in populations residing in the same geographical area.
以色列南部居住着贝都因人，他们的生活条件类似于发展中国家，而犹太人的生活条件则类似于发达国家。我们确定了这些人群中志贺氏菌属的流行病学情况。我们回顾性地分析了 2005 年至 2009 年期间志贺氏菌属的粪便分离株。总共分析了 3295 株分离株。S. sonnei 分离株在 3295 株中占 2057 株（62.4%），S. flexneri 分离株占 1058 株（32.1%）。1567 株（91.8%）从犹太患者中分离出 S. sonnei，而 931 株（60.4%）从贝都因人患者中分离出 S. flexneri。氨苄西林耐药性呈线性增加，从 2005 年的 373 株中的 217 株（58.2%）增加到 2009 年的 256 株中的 186 株（72.7%）（P < 0.001）。磺胺甲恶唑/甲氧苄啶耐药性呈线性下降，从 2005 年的 373 株中的 328 株（87.9%）下降到 2009 年的 256 株中的 133 株（51.9%）（P < 0.001）。在犹太患者中，志贺氏菌属对氨苄西林和磺胺甲恶唑/甲氧苄啶的耐药性更高：1706 株中的 1527 株（89.5%）比 1542 株中的 977 株（63.4%）（P < 0.0001），1706 株中的 1635 株（95.8%）比 1542 株中的 1026 株（66.5%）（P < 0.0001）。在同一地理区域居住的人群中，志贺氏菌属感染的流行病学情况可能有所不同。
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