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美国5至14岁儿童使用兴奋剂药物的患病率的地区差异:来自美国商业保险样本的结果。

Geographic variation in the prevalence of stimulant medication use among children 5 to 14 years old: results from a commercially insured US sample.

作者信息

Cox Emily R, Motheral Brenda R, Henderson Rochelle R, Mager Doug

机构信息

Office of Research and Development, Express Scripts, Inc, Maryland Heights, Missouri 63043, USA.

出版信息

Pediatrics. 2003 Feb;111(2):237-43. doi: 10.1542/peds.111.2.237.

DOI:10.1542/peds.111.2.237
PMID:12563045
Abstract

OBJECTIVE

The purpose of this study was to evaluate geographic variation in the prevalence of prescription stimulant use and predictors of use among a nationally representative, commercially insured population 5 to 14 years old.

METHODS

Prescription claims activity from January 1, 1999 through December 31, 1999 for a continuously eligible population 5 to 14 years old was evaluated. Age-gender adjusted prevalence rates were estimated for each state. Multivariate logistic regression using hierarchical linear modeling was used to evaluate the impact of age, gender, number of child dependents, and region of the country on stimulant prevalence. The contextual effects of urban or rural residence, median income, percent white, and physician rate per 100 000 residents were also controlled for.

RESULTS

The 1-year prevalence of stimulant treatment for the entire study sample was 4.2%. Multivariate logistic regression indicated that stimulant prescription use was positively associated with age, male gender, fewer child dependents, living in higher income communities, and living in communities with greater percent white. Compared with children living in the Western region of the country, children living in the Midwest and South were 1.55 (99% confidence interval: 1.28-1.87) and 1.71 (99% confidence interval: 1.42-2.06) times more likely to consume at least 1 stimulant medication, respectively. Differences in stimulant prevalence across urban and rural residence were also noted.

CONCLUSIONS

Geographic variation in the prevalence of stimulant use exists nationally, despite controlling for important predictors of use including age and gender. Possible reasons for the variation are discussed as are calls for additional research.

摘要

目的

本研究旨在评估在全国具有代表性的5至14岁商业保险人群中,处方兴奋剂使用的患病率的地理差异以及使用的预测因素。

方法

对1999年1月1日至1999年12月31日期间持续符合条件的5至14岁人群的处方索赔活动进行评估。估计每个州的年龄-性别调整患病率。使用分层线性模型的多变量逻辑回归来评估年龄、性别、受抚养子女数量和国家地区对兴奋剂患病率的影响。还控制了城乡居住情况、中位数收入、白人百分比和每10万居民的医生比例的背景效应。

结果

整个研究样本中兴奋剂治疗的1年患病率为4.2%。多变量逻辑回归表明,兴奋剂处方使用与年龄、男性性别、受抚养子女较少、生活在高收入社区以及生活在白人百分比更高的社区呈正相关。与居住在美国西部地区的儿童相比,居住在中西部和南部的儿童分别有1.55倍(99%置信区间:1.28 - 1.87)和1.71倍(99%置信区间:1.42 - 2.06)的可能性至少服用1种兴奋剂药物。还注意到城乡居住地区兴奋剂患病率的差异。

结论

尽管控制了包括年龄和性别在内的重要使用预测因素,但全国范围内兴奋剂使用的患病率仍存在地理差异。讨论了这种差异的可能原因,并呼吁进行更多研究。

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