Kikutani Hitoshi, Kumanogoh Atsushi
Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Nat Rev Immunol. 2003 Feb;3(2):159-67. doi: 10.1038/nri1003.
Although semaphorins were identified originally as guidance cues for developing neuronal axons, accumulating evidence indicates that several semaphorins are expressed also in the immune system. SEMA4D (CD100), which is expressed constitutively by T cells, enhances the activation of B cells and dendritic cells (DCs) through its cell-surface receptor, CD72. SEMA4A, which is expressed by DCs, is involved in the activation of T cells through interactions with TIM2. So, these semaphorins seem to function in the reciprocal stimulation of T cells and antigen-presenting cells (APCs). Emerging evidence indicates that additional semaphorins and related molecules are involved in T-cell-APC interactions also.
尽管信号素最初被鉴定为发育中神经元轴突的导向线索，但越来越多的证据表明，几种信号素也在免疫系统中表达。由T细胞组成性表达的SEMA4D（CD100），通过其细胞表面受体CD72增强B细胞和树突状细胞（DC）的活化。由DC表达的SEMA4A，通过与TIM2相互作用参与T细胞的活化。因此，这些信号素似乎在T细胞和抗原呈递细胞（APC）的相互刺激中发挥作用。新出现的证据表明，其他信号素和相关分子也参与T细胞与APC的相互作用。
