Liu Y, Yuan H, Lin D, Hu F, Liu Y, Zhang S, Zhao G, Jiang Q
Department of Epidemiology, Shanghai Medical University, Shanghai 200032.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1999;17(3):149-51.
To explore the family aggregation of advanced schistosomiasis japonica.
Eighty-one cases of advanced schistosomiasis(AS) and 67 cases of non-advanced schistosomiasis with history of infections in Yushan County, Jiangxi Province were chosen as proband groups and control groups respectively, then grades 1 and 2 relatives of them were investigated on AS. Family aggregation of AS was analyzed through comparing the prevalence rate between the close and distant relatives of probands and controls and fitting the observed distribution of AS cases among the population by zero-truncated Poisson distribution and zero-truncated negative binomial distribution.
The prevalence rate was higher in the close relatives (Group I relatives) of the probands than in the distant relatives(Group II relatives) of the probands and in the controls' relatives. The observed distribution of AS was beyond the probability of the zero-truncated Poisson distribution, but consistent with the zero-truncated negative binomial distribution.
Family aggregation of advanced schistosomiasis does exist.
探讨晚期日本血吸虫病的家庭聚集性。
选取江西省玉山县81例晚期血吸虫病患者和67例有感染史的非晚期血吸虫病患者分别作为先证者组和对照组，然后对其一级和二级亲属进行晚期血吸虫病调查。通过比较先证者和对照组的近亲和远亲之间的患病率，并采用零截尾泊松分布和零截尾负二项分布对人群中晚期血吸虫病病例的观察分布进行拟合，分析晚期血吸虫病的家庭聚集性。
先证者的近亲（I组亲属）的患病率高于先证者的远亲（II组亲属）和对照组亲属。晚期血吸虫病的观察分布超出了零截尾泊松分布的概率，但与零截尾负二项分布一致。
晚期血吸虫病确实存在家庭聚集性。
