犬免疫介导性发热。血清中抗核抗体、类风湿因子、肿瘤坏死因子及白细胞介素-6的出现情况。
Immune-mediated fever in the dog. Occurrence of antinuclear antibodies, rheumatoid factor, tumor necrosis factor and interleukin-6 in serum.
作者信息
Bohnhorst J Ovrebø, Hanssen I, Moen Torolf
机构信息
Department of Immunology and Transfusion Medicine, University Hospital of Trondheim, Trondheim, Norway.
出版信息
Acta Vet Scand. 2002;43(3):165-71. doi: 10.1186/1751-0147-43-165.
Contents of antinuclear antibodies (ANA), rheumatoid factor (RF), tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) were measured in serum from 20 dogs with immune-mediated fever. Seven out of 20 patients were ANA positive, 1 out of 20 was positive to antibodies against extractable nuclear antigens (ENA), 1 out of 20 was positive to antibodies against deoxynucleoproteins (DNP), 2 out of 13 were RF positive and none out of 20 patients had antibodies against native DNA in the serum. TNF-alpha was not detected in any serum of 15 dogs with immune-mediated fever, while 10 out of 13 presented with elevated IL-6. The results varied between patients, but the IL-6 level was high in most of them. This indicate a role for IL-6 in the pathogenesis of immune-mediated fever in most cases.
检测了20只患有免疫介导性发热的犬血清中的抗核抗体（ANA）、类风湿因子（RF）、肿瘤坏死因子（TNF-α）和白细胞介素-6（IL-6）含量。20例患者中有7例ANA呈阳性，20例中有1例对可提取核抗原（ENA）抗体呈阳性，20例中有1例对脱氧核蛋白（DNP）抗体呈阳性，13例中有2例RF呈阳性，20例患者血清中均无抗天然DNA抗体。15只患有免疫介导性发热的犬的任何血清中均未检测到TNF-α，而13例中有10例IL-6升高。患者之间结果存在差异，但大多数患者的IL-6水平较高。这表明在大多数情况下IL-6在免疫介导性发热的发病机制中起作用。
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