Benhamou Nathanael, Massin Pascale, Haouchine Belkacem, Audren Francois, Tadayoni Ramin, Gaudric Alain
Department of Ophthalmology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris 7, Paris, France.
Am J Ophthalmol. 2003 Feb;135(2):246-9. doi: 10.1016/s0002-9394(02)01938-4.
To evaluate the efficacy of intravitreal triamcinolone in refractory pseudophakic cystoid macular edema.
A prospective, interventional case series.
Three eyes of three patients with longstanding pseudophakic cystoid macular edema following uncomplicated cataract surgery, refractory to any medication, were treated with 8 mg of intravitreal triamcinolone. All three eyes were evaluated before injection and throughout follow-up with the Early Treatment Diabetic Retinopathy Study's visual acuity chart, fluorescein angiography, and macular mapping using optical coherence tomography.
A month after intravitreal triamcinolone injection, a dramatic decrease in macular thickness was noted by optical coherence tomography in all three eyes (from a mean of 502-233 microm). Mean improvement in visual acuity was 3.7 Snellen lines. Two to 4 months after triamcinolone injection, however, the edema recurred in all cases, to the same degree as before the injection, combined with a decrease in vision. Two eyes underwent a second injection of triamcinolone, and macular thickness decreased, but the edema again recurred 3 months after injection.
Intravitreal injection of triamcinolone induces striking regression, within 1 month, of chronic refractory macular edema. This regression appears to be transient, however, even after a second injection.
评估玻璃体内注射曲安奈德治疗难治性人工晶状体眼黄斑囊样水肿的疗效。
一项前瞻性干预性病例系列研究。
选取3例患者的3只眼，这些患者在白内障手术未出现并发症后长期存在人工晶状体眼黄斑囊样水肿，对任何药物治疗均无效，给予玻璃体内注射8 mg曲安奈德治疗。在注射前以及整个随访过程中，使用糖尿病视网膜病变早期治疗研究的视力表、荧光素血管造影以及光学相干断层扫描进行黄斑测绘，对所有3只眼进行评估。
玻璃体内注射曲安奈德1个月后，光学相干断层扫描显示所有3只眼的黄斑厚度显著降低（从平均502微米降至233微米）。平均视力提高了3.7行Snellen视力表。然而，在曲安奈德注射后2至4个月，所有病例的水肿均复发，程度与注射前相同，同时视力下降。2只眼接受了第二次曲安奈德注射，黄斑厚度降低，但注射后3个月水肿再次复发。
玻璃体内注射曲安奈德可在1个月内使慢性难治性黄斑水肿显著消退。然而，即使进行第二次注射，这种消退似乎也是短暂的。
