Guan Y H, Lilley T H, Lath D L, Marlow I, Brook A H
University of Sheffield and Boots National Centre for Applied Research into Oral Health, School of Clinical Dentistry, Sheffield, UK.
Caries Res. 2003 Jan-Feb;37(1):71-8. doi: 10.1159/000068222.
Binary poly(oxypropylene-oxyethylene) block copolymer systems have been investigated as a non-bactericidal approach to reduce the retention of an oral bacterium, Streptococcus sanguis. Using a previously validated hydroxyapatite-coated microtitre model to simulate the tooth, the performance of copolymer pairs was measured experimentally. A synergy index and an efficacy index were defined to describe the reduction of bacterial retention by the binary systems that comprise the copolymer pairs. Relationships between the synergy and efficacy indices and their associated compositions are given. The results obtained have been rationalised using a previously developed theoretical approach in conjunction with the binding energetics of species to surfaces.
二元聚（氧化丙烯-氧化乙烯）嵌段共聚物体系已被研究作为一种非杀菌方法来减少口腔细菌血链球菌的滞留。使用先前验证的羟基磷灰石包被的微量滴定模型来模拟牙齿，通过实验测量了共聚物对的性能。定义了协同指数和功效指数来描述由共聚物对组成的二元体系对细菌滞留的减少情况。给出了协同指数和功效指数与其相关组成之间的关系。结合先前开发的理论方法以及物质与表面的结合能，对所得结果进行了合理化分析。
