Zhang Zai-xing, Li Chong-zhen, Huang Guo-zhen, Yang Ya-ming, Zhou Sheng, Sun Xiao-dong, Li Li
Yunnan Institute of Parasitic Diseases Prevention, Simao 665000.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2002;20(2):94-7.
To investigate the failure of treatment with chloroquine in Yunnan in order to help formulate adequate antimalarial drug policy.
A World Health Organization 28-day in vivo test on therapeutic response for uncomplicated falciparum malaria in area with low or moderate transmission was adopted. Patients of age > or = 6 months old were admitted without limitation in density of parasitaemia and body temperature. Clinical and parasitological observation was conducted for patients on day 0, 1, 2, 3, 4, 7, 14, 21, 28 and 35.
Of 62 patients identified as malaria cases infected by Plasmodium falciparum only, Plasmodium vivax only or by both species, 52 cases infected by Plasmodium falciparum only were included in the study. The overall treatment failure rate was 40.7%, with early treatment failure (ETF) rate of 1.8% and late treatment failure rate (LTF) of 38.9%.
The treatment failure rate was much higher than the rate of 25% recommended by WHO. It is suggested that use of single chloroquine should be stopped in the treatment of falciparum malaria cases in such area. No relationship was found between the failure rate and the density of malaria parasites.
调查云南氯喹治疗失败情况，以助制定合适的抗疟药物政策。
采用世界卫生组织针对低或中度传播地区非复杂性恶性疟原虫疟疾治疗反应的28天体内试验。年龄≥6个月的患者入院，对疟原虫血症密度和体温无限制。在第0、1、2、3、4、7、14、21、28和35天对患者进行临床和寄生虫学观察。
在62例仅感染恶性疟原虫、仅感染间日疟原虫或同时感染两种疟原虫的疟疾病例中，仅感染恶性疟原虫的52例患者纳入研究。总体治疗失败率为40.7%，早期治疗失败（ETF）率为1.8%，晚期治疗失败（LTF）率为38.9%。
治疗失败率远高于世界卫生组织推荐的25%的比率。建议在此类地区停止使用单一氯喹治疗恶性疟病例。未发现失败率与疟原虫密度之间的关系。
