Wei Q F, Gao X Z
Department of Parasitology, Beijing Medical School, Beijing 101300.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000;18(4):197-9.
To study the effect of anti-mosquito-midgut antibodies on the development of P. yoelii in A. stephensi.
Ookinetes and oocysts in midgut and sporozoites in the salivary glands of mosquitoes were examined respectively at 14 h and 9 d and 12 d after the mosquitoes ingested infected blood containing anti-midgut antibodies by membrane feeders. The effect of anti-midgut antibody level and repeated feedings on the development of the oocysts in the mosquitoes was also observed.
The anti-midgut antibodies reduced evidently not only the infection rates of the oocysts and the number of the sporozoites in salivary gland but also infection degree of ookinetes and the index of oocysts in the mosquitoes compared with control group (P < 0.05). The higher the antibody level, the more the times for mosquitoes digested antibodies, and the fewer the number of oocysts.
The anti-mosquito-mindgut antibodies inhibited ookinetes and oocysts of P. yoelii in A. stephensi, with oocysts in particular.
研究抗蚊中肠抗体对约氏疟原虫在斯氏按蚊体内发育的影响。
通过膜饲法让蚊子摄取含抗中肠抗体的感染血液后，分别于14小时、9天和12天检查蚊子中肠内的动合子和卵囊以及唾液腺内的子孢子。还观察了抗中肠抗体水平和重复饲血对蚊子体内卵囊发育的影响。
与对照组相比，抗中肠抗体明显降低了卵囊感染率、唾液腺内子孢子数量，以及动合子感染程度和蚊子体内卵囊指数（P<0.05）。抗体水平越高、蚊子消化抗体次数越多，卵囊数量就越少。
抗蚊中肠抗体抑制了约氏疟原虫在斯氏按蚊体内的动合子和卵囊，尤其是卵囊。
