Nadal-Ginard Bernardo, Kajstura Jan, Leri Annarosa, Anversa Piero
Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA.
Circ Res. 2003 Feb 7;92(2):139-50. doi: 10.1161/01.res.0000053618.86362.df.
The accepted paradigm considers the adult mammalian heart as a postmitotic organ, which possesses a relatively constant number of myocytes from shortly after birth to adulthood and senescence. This notion is questioned by the demonstration that although most adult myocytes are terminally differentiated, there is a small and continuously renewed subpopulation of cycling myocytes produced by the differentiation of cardiac stem-like cells. Myocyte death and myocyte regeneration are introduced as major determinants of cardiac homeostasis and alterations of ventricular anatomy and function in physiological and pathological states. The possibility of reconstituting dead myocardium by stem-like cells is advanced and proposed as a major area of future research.
公认的范式认为成年哺乳动物心脏是一个有丝分裂后器官，从出生后不久到成年及衰老阶段，其心肌细胞数量相对恒定。然而，有证据表明，尽管大多数成年心肌细胞已终末分化，但仍存在一小部分由心脏干细胞样细胞分化产生的不断更新的循环心肌细胞亚群，这一观点受到了质疑。心肌细胞死亡和再生被认为是心脏稳态以及生理和病理状态下心室解剖结构和功能改变的主要决定因素。利用干细胞样细胞重建死亡心肌的可能性被提出，并被视为未来研究的一个主要领域。
