Sarathkumar Elangovan, Victor Marina, Menon Jaivardhan A, Jibin Kunnumpurathu, Padmini Suresh, Jayasree Ramapurath S
Division of Biophotonics and Imaging, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Biomedical Technology Wing Trivandrum India
Sree Narayana Institute of Medical Sciences Kochi Kerala India.
RSC Adv. 2021 Oct 26;11(55):34572-34588. doi: 10.1039/d1ra06404e. eCollection 2021 Oct 25.
The wide arena of applications opened by nanotechnology is multidimensional. It is already been proven that its prominence can continuously influence human life. The role of stem cells in curing degenerative diseases is another major area of research. Cardiovascular diseases are one of the major causes of death globally. Nanotechnology-assisted stem cell therapy could be used to tackle the challenges faced in the management of cardiovascular diseases. In spite of the positive indications and proven potential of stem cells to differentiate into cardiomyocytes for cardiac repair and regeneration during myocardial infarction, this therapeutic approach still remains in its infancy due to several factors such as non-specificity of injected cells, insignificant survival rate, and low cell retention. Attempts to improve stem cell therapy using nanoparticles have shown some interest among researchers. This review focuses on the major hurdles associated with cardiac stem cell therapy and the role of nanoparticles to overcome the major challenges in this field, including cell modulation, imaging, tracking and gene delivery.
纳米技术开启的广泛应用领域是多维度的。已经证明，其突出地位能够持续影响人类生活。干细胞在治疗退行性疾病中的作用是另一个主要研究领域。心血管疾病是全球主要死因之一。纳米技术辅助的干细胞疗法可用于应对心血管疾病管理中面临的挑战。尽管干细胞具有积极的迹象和已被证实的分化为心肌细胞以在心肌梗死期间进行心脏修复和再生的潜力，但由于诸如注射细胞的非特异性、存活率低和细胞滞留率低等多种因素，这种治疗方法仍处于起步阶段。利用纳米颗粒改善干细胞疗法的尝试已引起研究人员的一些兴趣。本综述重点关注与心脏干细胞疗法相关的主要障碍以及纳米颗粒在克服该领域主要挑战（包括细胞调节、成像、追踪和基因递送）方面的作用。
