Christiansen P, Andersson A-M, Skakkebaek N E
Department of Growth and Reproduction, Rigshospitalet, DK-2100 Copenhagen, Denmark.
J Clin Endocrinol Metab. 2003 Feb;88(2):888-91. doi: 10.1210/jc.2002-021379.
The aim of the study was to investigate the longitudinal changes of inhibin B in a group of patients with Klinefelter syndrome (KS; karyotype 47,XXY) progressing through puberty and to compare them to a group of age- and puberty-matched controls. Seven boys with nonmosaic KS (karyotype 47,XXY) and 11 controls were followed with longitudinal serum inhibin B measurements every 3-12 months as they approached and entered puberty. None of the boys had significant bone age delay, and all entered puberty at the normal time and progressed through it at the expected time. In addition, 15 young adults with KS, aged 16.7-29.5 yr, were studied. We found normal levels of inhibin B in prepubertal boys with KS and controls. In patients with KS as well as controls, inhibin B increased progressively before clinical pubertal onset. However, during late puberty inhibin B levels decreased gradually to the low/unmeasurable levels observed later in adult KS, while remaining unchanged in the controls.
本研究的目的是调查一组患有克兰费尔特综合征（KS；核型47,XXY）的患者在青春期发育过程中抑制素B的纵向变化，并将其与一组年龄和青春期发育阶段相匹配的对照组进行比较。对7名非嵌合型KS（核型47,XXY）男孩和11名对照组男孩在接近青春期和进入青春期时，每3 - 12个月进行一次血清抑制素B的纵向测量。所有男孩的骨龄均无明显延迟，均在正常时间进入青春期，并按预期时间度过青春期。此外，还对15名年龄在16.7 - 29.5岁的KS青年进行了研究。我们发现青春期前的KS男孩和对照组男孩的抑制素B水平正常。在KS患者和对照组中，抑制素B在临床青春期开始前逐渐升高。然而，在青春期后期，抑制素B水平逐渐下降至成年KS患者后期观察到的低水平/不可测水平，而对照组则保持不变。
