Brada Z, Bulba S
Res Commun Chem Pathol Pharmacol. 1976 Jan;13(1):19-26.
L-[ethyl-2-14C] ethionine was administered in a single dose to rats fed a diet containing 0.10% alpha-naththyl isothiocyanate for a period of time between 6 and 99 days. Ethionine metabolites excreted into urine were investigated as a function of induced pathologic changes in the liver. A short-time exposure (6 and 14 days) to alpha-naththyl isothiocyanate increased the excretion of free ethionine and S-adenosylethionine at the expense of total ethionine sulfoxide. With the extended feeding period the excretion of total ethionine sulfoxide became normalized while the excretion of free ethionine and S-adenosylethionine decreased. The acetylated fraction of ethionine sulfoxide decreased rapidly and reached a minimum in 14 days of feeding. This fraction subsequently started to increase, but did not reach the values obtained in normal rats.
将单剂量的L-[乙基-2-¹⁴C]乙硫氨酸给予喂食含0.10%α-萘基异硫氰酸酯饮食的大鼠，持续6至99天。研究了排泄到尿液中的乙硫氨酸代谢产物与肝脏中诱导的病理变化之间的关系。短期暴露（6天和14天）于α-萘基异硫氰酸酯会增加游离乙硫氨酸和S-腺苷乙硫氨酸的排泄，而总乙硫氨酸亚砜的排泄减少。随着喂食时间延长，总乙硫氨酸亚砜的排泄恢复正常，而游离乙硫氨酸和S-腺苷乙硫氨酸的排泄减少。乙硫氨酸亚砜的乙酰化部分迅速下降，并在喂食14天时达到最低值。该部分随后开始增加，但未达到正常大鼠的水平。
