Brada Z, Bulba S, Altman N H
Cancer Res. 1976 May;36(5):1573-9.
The concentration of S-adenosylethionine in the liver of ethionine-fed rats was increased gradually during the process of carcinogenesis. This increase may have been due to the decreased capacity of the treated rats to acetylate ethionine sulfoxide. Ethionine sulfoxide is considered as the main reserve pool of ethionine for the synthesis of S-adenosylethionine. When the ethionine diet was supplemented by DL-methionine (0.3 to 0.9%), the increase in the concentration of S-adenosylethionine during the period of observation (28 to 150 days) was lower and the acetylation of ethionine sulfoxide was significantly higher. The concentration of the total S-adenosyl compounds in the liver of rats on a diet supplemented with DL-methionine was increased over the concentration of S-adenosylethionine in rats fed ethionine alone, and the S-adenosylethionine portion of this fraction was only about 30% lower. The supplementation of the diet with methionine restored the diurnal oscillation of adenosine 5'-triphosphate in the liver, which had been absent in rats ingesting only ethionine.
在给大鼠喂食乙硫氨酸的致癌过程中，其肝脏中S-腺苷乙硫氨酸的浓度逐渐升高。这种升高可能是由于受试大鼠乙酰化乙硫氨酸亚砜的能力下降所致。乙硫氨酸亚砜被认为是用于合成S-腺苷乙硫氨酸的乙硫氨酸的主要储备库。当在乙硫氨酸饮食中补充DL-蛋氨酸（0.3%至0.9%）时，在观察期（28至150天）内S-腺苷乙硫氨酸浓度的升高较低，且乙硫氨酸亚砜的乙酰化显著更高。喂食补充了DL-蛋氨酸饮食的大鼠肝脏中总S-腺苷化合物的浓度高于仅喂食乙硫氨酸的大鼠肝脏中S-腺苷乙硫氨酸的浓度，且该部分中S-腺苷乙硫氨酸的比例仅低约30%。饮食中补充蛋氨酸恢复了肝脏中三磷酸腺苷的昼夜振荡，而仅摄入乙硫氨酸的大鼠中这种振荡并不存在。
