Sved S, Hossie R D, McGilveray I J
Res Commun Chem Pathol Pharmacol. 1976 Feb;13(2):185-92.
Theophylline peak plasma concentration of over 170 ng/ml average was observed when 300 mg of caffeine, equivalent to 2-3 cups of coffee, was administered to humans. This peak level was not observed until at least 7 hr post administration. Accumulation of caffeine, with its subsequent metabolism to theophylline, in patients, who consume average quantities of caffeine-containing beverages relative to those patients who avoid such drinks could interfere with bioavailability studies in normal volunteers. However, it may account for only a small portion of the variable clinical effects associated with aminophylline administration.
当给人类服用相当于2至3杯咖啡的300毫克咖啡因时，观察到茶碱的平均血浆峰值浓度超过170纳克/毫升。直到给药后至少7小时才观察到这个峰值水平。相对于那些避免饮用含咖啡因饮料的患者，饮用平均量含咖啡因饮料的患者体内咖啡因的积累及其随后代谢为茶碱的过程，可能会干扰正常志愿者的生物利用度研究。然而，它可能仅占与氨茶碱给药相关的临床效果差异的一小部分。
