Madersbacher Stephen, Schmidt Jochen, Eberle Johannes M, Thoeny Harriet C, Burkhard Fiona, Hochreiter Werner, Studer Urs E
Department of Urology, University of Bern, Switzerland.
J Urol. 2003 Mar;169(3):985-90. doi: 10.1097/01.ju.0000051462.45388.14.
Ileal conduit is considered a safe procedure and the gold standard to which newer forms of urinary diversion should be compared, although few long-term results are known. We analyzed a consecutive series of patients who lived a minimum of 5 years after ileal conduit diversion.
A total of 412 patients underwent ileal conduit diversion between 1971 and 1995 at our institution. We analyzed all conduit related complications occurring later than 3 months after surgery in 131 long-term survivors (survival 5 years or greater).
Median followup was 98 months (range 60 to 354). Overall 192 conduit related complications developed in 87 of 131 (66%) patients. The most frequent complications were related to kidney function/morphology in 35 patients (27%), stoma in 32 (24%), bowel in 32 (24%), symptomatic urinary tract infection (including pyelonephritis) in 30 (23%), conduit/ureteral anastomosis in 18 (14%) and urolithiasis in 12 (9%). Within the first 5 years complications developed in 45% of patients. This percentage increased to 50%, 54% and 94% in those surviving 10, 15 and longer than 15 years, respectively. In this last group 50% had upper urinary tract changes and 38% had urolithiasis, for which the respective numbers after 5 years were 12% and 17%.
This study demonstrates a high conduit related complication rate in long-term survivors and underlines the need for vigorous long-term followup. Only studies lasting more than 1 decade cover the entire morbidity spectrum.
回肠代膀胱术被认为是一种安全的手术方法,也是新的尿流改道形式应与之比较的金标准,尽管其长期结果鲜为人知。我们分析了一系列连续的患者,这些患者在回肠代膀胱术后至少存活了5年。
1971年至1995年间,我院共有412例患者接受了回肠代膀胱术。我们分析了131例长期存活者(存活5年或更长时间)在术后3个月后发生的所有与导管相关的并发症。
中位随访时间为98个月(范围60至354个月)。131例患者中有87例(66%)发生了192例与导管相关的并发症。最常见的并发症与肾功能/形态有关,有35例(27%);造口相关的有32例(24%);肠道相关的有32例(24%);有症状的尿路感染(包括肾盂肾炎)30例(23%);导管/输尿管吻合相关的有18例(14%);尿路结石12例(9%)。在最初5年内,45%的患者出现并发症。在存活10年、15年和超过15年的患者中,这一比例分别增至50%、54%和94%。在最后一组中,50%的患者有上尿路改变,38%的患者有尿路结石,而5年后这两个比例分别为12%和17%。
本研究表明长期存活者中与导管相关的并发症发生率较高,并强调了进行积极长期随访的必要性。只有持续超过10年的研究才能涵盖整个发病谱。