Paick Jae-Seung, Park Jae Young, Park Dal Woo, Park Kwanjin, Son Hwancheol, Kim Soo Woong
Department of Urology, Seoul National University College of Medicine and Seoul Boramae Hospital, Korea.
J Urol. 2003 Mar;169(3):1052-5. doi: 10.1097/01.ju.0000052666.97595.f6.
We analyzed our experience with repeat microsurgical vasovasostomy after failed vasovasostomy and elucidate the possible predictors of surgical outcome.
We evaluated 62 repeat vasectomy reversal cases with followup data available. Regardless of the intraoperative observation of sperm in the vasal fluid bilateral microsurgical 2-layer vasovasostomy was performed when surgically possible. Of these 62 patients 60 (97%) underwent bilateral (58) or unilateral (2) vasovasostomy and 2 (3%) underwent unilateral vasovasostomy with contralateral epididymovasostomy.
Patency and pregnancy followup data were available on 62 and 42 patients, respectively. The overall patency and pregnancy rates achieved were 92% and 57%, respectively, and the natural birth rate was 52%. Increased age of the wife proved a negative prognostic factor for pregnancy (p = 0.018). The intraoperative detection of sperm and other factors, including obstructive interval, reconstruction type, anastomotic site, patient age and postoperative semen parameters, did not influence the surgical outcome.
Regardless of the detection of sperm in the intravasal fluid during the operation repeat microsurgical vasovasostomy resulted in a better outcome than in other studies, in which adopted epididymovasostomy was done when sperm was absent from the vas fluid. Our study suggests that compromised anastomosis after previous surgery is the most common cause of failed vasovasostomy. We recommend that microsurgical vasovasostomy should be performed preferentially in failed vasovasostomy cases.
我们分析了输精管吻合术失败后再次显微外科输精管吻合术的经验,并阐明手术结果的可能预测因素。
我们评估了62例有随访数据的再次输精管复通病例。无论术中在输精管液中观察到精子与否,只要手术可行,均进行双侧显微外科两层输精管吻合术。在这62例患者中,60例(97%)接受了双侧(58例)或单侧(2例)输精管吻合术,2例(3%)接受了单侧输精管吻合术并同期进行了对侧附睾输精管吻合术。
分别有62例和42例患者获得了通畅情况和妊娠情况的随访数据。总体通畅率和妊娠率分别为92%和57%,自然分娩率为52%。妻子年龄增加被证明是妊娠的一个负面预后因素(p = 0.018)。术中精子检测及其他因素,包括梗阻时间、重建类型、吻合部位、患者年龄和术后精液参数,均不影响手术结果。
无论术中输精管液中是否检测到精子,再次显微外科输精管吻合术的结果均优于其他研究,在其他研究中,当输精管液中无精子时采用附睾输精管吻合术。我们的研究表明,既往手术导致的吻合口受损是输精管吻合术失败的最常见原因。我们建议,在输精管吻合术失败的病例中应优先进行显微外科输精管吻合术。