Dong Yue-lan, Li Chun-hua, Chen Li-xin, Feng Huai-ying, Zhu Bao-sheng
Department of Gynecology, the First People's Hospital of Yunnan Province, Kunming, PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Feb;20(1):59-60.
To detect the relationship between chromosomal anomalies and the pathogenesis, development and prognosis of ovarian carcinoma.
Thirty-six specimens of ovarian carcinoma (n=12), ovarian benign tumor (n=12), and normal ovary (n=12) were examined by fluorescence in situ hybridization (FISH).
Twelve cases of mutations, including trisomy 8, monosomy 8 or tetraploid 8 chromosomal anomalies, were found in the group of ovarian carcinoma, making up 100% (12/12). Three cases of trisomy 8 chromosomal anomalies were found in the group of ovarian benign tumor, accounting for 25% (3/12). No anomaly was found in the normal group. There were significant differences between the three groups, P<0.001.
The above anomalies of chromosome 8 are significantly associated with the pathogenesis and development of ovarian carcinoma. The anomalies may occur in the early stage of the carcinoma, and may be significantly associated with the pathological differentiation and clinical stage of the case.
检测染色体异常与卵巢癌发病机制、发展及预后之间的关系。
采用荧光原位杂交（FISH）技术检测36份标本，其中卵巢癌12例、卵巢良性肿瘤12例、正常卵巢12例。
卵巢癌组发现12例突变，包括8号染色体三体、8号染色体单体或8号染色体四倍体异常，占100%（12/12）。卵巢良性肿瘤组发现3例8号染色体三体异常，占25%（3/12）。正常组未发现异常。三组间差异有统计学意义，P<0.001。
上述8号染色体异常与卵巢癌的发病机制及发展显著相关。这些异常可能在癌症早期出现，且可能与病例的病理分化及临床分期显著相关。
