Xiang Guang-da, Hu Tai-hong, Wang Yun-lin
Department of Endocrinology, Wuhan General Hospital of PLA, Wuhan, Hubei, PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Feb;20(1):66-8.
To investigate the relationship between carotid artery intima media thickness (IMT) and apolipoprotein (Apo) E gene polymorphisms in type 2 diabetes mellitus (DM2).
Two hundred and fifty-five DM2 patients without angiopathy and 107 healthy individuals were selected. PCR/allele-specific oligonucleotide probe was used to determine their apoE genotypes.
The prevalence distribution of apoE genotypes and alleles in DM2 patients and that in controls were similar. The TC, LDL-C and Lp(a) concentrations in e4/4, e4/3 subgroups were significantly higher than those in e3/2, e2/2 subgroups (P<0.05). The average value of IMT in e4/4 e4/3 carriers (0.89 mm) was significantly greater than that in e3/2 e2/2 carriers (0.62 mm) (P<0.05). After adjustment for TC, LDL-C, TG, Lp(a), FBG, HbA1c, age, BMI, and smoking, ANCOVA showed that the average value of carotid IMT was significantly greater in subjects with e4/4 e4/3, compared with that in subjects with e3/2 e2/2(P=0.033).
Apo e4 allele increases the risk for carotid artery atherosclerosis in the early stage of diabetic population.
探讨2型糖尿病（DM2）患者颈动脉内膜中层厚度（IMT）与载脂蛋白（Apo）E基因多态性之间的关系。
选取255例无血管病变的DM2患者和107例健康个体。采用聚合酶链反应/等位基因特异性寡核苷酸探针法测定其载脂蛋白E基因型。
DM2患者与对照组载脂蛋白E基因型和等位基因的患病率分布相似。e4/4、e4/3亚组的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和脂蛋白（a）[Lp（a）]浓度显著高于e3/2、e2/2亚组（P<0.05）。e4/4、e4/3基因型携带者的IMT平均值（0.89mm）显著高于e3/2、e2/2基因型携带者（0.62mm）（P<0.05）。在对TC、LDL-C、甘油三酯（TG）、Lp（a）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、年龄、体重指数（BMI）和吸烟情况进行校正后，协方差分析显示，e4/4、e4/3基因型受试者的颈动脉IMT平均值显著高于e3/2、e2/2基因型受试者（P=0.033）。
载脂蛋白E4等位基因增加糖尿病患者早期颈动脉粥样硬化风险。
