Xu L, Xu S P
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Yao Xue Xue Bao. 2001 Feb;36(2):100-4.
To synthesize derivatives of 2-[substituted phenyl)vinyl] indole and find compounds with biological activities by screening in vitro.
Twenty-one compounds of 2-[(substituted phenyl) vinyl] indole were synthesized by reduction, oxidation and Witting reaction. MS, 1HNMR and elemental analysis were used to determine the structures of the new compounds.
These compounds are new ones.
Six compounds (3, 9, 11, 13, 18 and 20) showed effects on some different receptors, such as alpha 2, D2 and H1, and is worth further studying.
合成2-[(取代苯基)乙烯基]吲哚衍生物，并通过体外筛选寻找具有生物活性的化合物。
通过还原、氧化和维蒂希反应合成了21种2-[(取代苯基)乙烯基]吲哚化合物。采用质谱、1H核磁共振和元素分析确定新化合物的结构。
这些化合物均为新化合物。
6种化合物（3、9、11、13、18和20）对某些不同受体，如α2、D2和H1有作用，值得进一步研究。
