Dev P K, Srivastava P N
Strahlentherapie. 1976 Mar;151(3):258-73.
A study has been made on the effects of P-32 on the developing thyroid gland of Swiss albino mice. The series of experiments reveal that: (I) P-32 at the dose rate of 1.0 muCi/g body-weight to the seven-day pregnant mouse has almost no effect on the 18-day foetus or as late as 14-day postnatal thyroid. (II) With the same dose, when given to one-day-old mouse, signs of dead mitotic figures are noticed. The effects are more pronounced in the beginning, but after the fourth week no morphological changes are seen. (III) When a seven-day-old animal is injected with the same dose, dead cells are found in the earlier stages followed by the damage to the vascular structure of the epithelium. (IV) The 14-day injected group shows damage to the epithelium in the form of condensed nuclei and loss of colloid from the follicles. Replacement of follicles by fatty degeneration is evident. (V) A maximum susceptibility to P-32 irradiation is shown by 21-day-old injected animals, where epithelial desquamation and replacement of follicles by fatty degeneration are easily marked one week after the injection. (VI) In the last group, where P-32 is given at the 28th day after parturition, there may be a tendency of the thickening of the blood vessels. (VII) The females show a greater damage to P-32 injection than the males in the postnatal period studied.
一项关于P-32对瑞士白化小鼠发育中的甲状腺影响的研究已经展开。一系列实验表明：（I）以1.0微居里/克体重的剂量率给怀孕七天的小鼠注射P-32，对18天的胎儿或直至出生后14天的甲状腺几乎没有影响。（II）给予相同剂量，当注射给一日龄小鼠时，可观察到有丝分裂死亡细胞的迹象。最初影响更为明显，但四周后未见形态学变化。（III）当给七日龄动物注射相同剂量时，早期可发现死亡细胞，随后上皮的血管结构受损。（IV）注射14天组显示上皮受损，表现为细胞核浓缩和滤泡胶体丧失。滤泡被脂肪变性取代很明显。（V）21日龄注射动物对P-32辐射表现出最大易感性，注射一周后上皮脱屑和滤泡被脂肪变性取代很容易被观察到。（VI）在最后一组中，即在产后第28天给予P-32，可能存在血管增厚的趋势。（VII）在所研究的出生后时期，雌性小鼠对P-32注射的损伤比雄性更大。
